Osteosarcoma is a form of bone cancer in dogs that accounts for 85% of primary bone tumors diagnosed, making it the most common bone tumor. It is a highly aggressive tumor, characterized by local invasion and destruction of the bone as well as early metastasis (spread to other organs, the most common site of metastasis being the lungs). Osteosarcoma most commonly affects the limbs (or the appendicular skeleton) of large to giant breed dogs. It can also occur in other bones such as the skull, ribs, vertebrae, and pelvis (the axial skeleton) which are more common sites in smaller dogs.
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